The National Brewing Company

Of course the most popular and well known brewery of Baltimore is the National Brewing Company located on Brewers Hill in the neighborhood of Canton. The brewery is famous for producing National Bohemian Beer or "Natty Boh" is still favored and sold in practically every bar and liquor store in the city. The official website of the National Bohemian Beer has a great little history page that gives some brief information about the breweries past http://www.nationalbohemian.com/history/Default.aspx.
This is only a portion of the information that I found on the website that I will provide on this post. The brewery began to brew Natty Boh in 1885 although their mascot "Mr. Boh" was introduced after prohibition. If you look throughout the city you can see Mr. Boh which has become somewhat of a prized symbol in the city. The National Brewery was also the first brewery to produced canned beer in six packs in the late 1940's. In 1965 the brewery became the official sponsor of the Baltimore Orioles and was proudly served at Memorial stadium and even today at Camden Yards.
This website also has a really nice picture page of the "Natty Boh" and "Mr. Boh" logo's taken throughout Baltimore. One reason why this brewery and beer has such an important impact on Baltimore's Brewing History and the city's culture is the poll that is taken on it's website. The poll asks, "Why do you drink Natty Boh?," and the best answer was "Baltimore Pride". "My Parents Drank it," "It's affordable," and "It's really good," were the next three answers in descending in order.

No Author Given, “History,” NationalBohemian.com, http://www.nationalbohemian.com/history/Default.aspx (accessed December 12, 2009).